A minimal electrophysiological model of gastric smooth muscle cell based on effective ionic currents

Abstract

Electrophysiological cell models are used to study and simulate the electrical behavior of cells. These models are presented by considering the characteristics of cells, channels, and ion currents in the cell membrane. This study aimed to provide a minimal model for gastric smooth muscle cells. Using the sensitivity analysis method in this paper, gastric cell current from the colon cell was obtained based on the approach of Yeoh et al. Then, the minimal model was obtained by identifying effective ion currents and eliminating inefficient ion currents. To evaluate the minimal model, the criteria of slow wave index points (initial potential, maximum spike potential, minimum valley potential, maximum plateau potential, and resting potential) and action potential duration of 10, 50, and 90 were used. Then, These values were compared with the slow wave physiological state of gastric smooth muscle cells. Finally, the minimal model obtained was consistent with the physiological model. The largest difference between the index points in both cases was related to the maximum spike potential with 2.21 millivolt and the action potential duration of 10 with 9 milliseconds. The results obtained by comparing two models of gastric smooth muscle cells (physiological and minimal states) showed the same behavior in slow wave.

Keywords

• minimal model
• electrophysiology
• slow wave
• ion channels
• smooth muscle cell
• gastric