Clinical analysis of 23 cases of adult reversible splenial lesion syndrome

Abstract

Objective To analyze the clinical features and mechanism of reversible splenial lesion syndrome (RESLES) in adults. Methods and Results Twenty ⁃ three patients with reversible splenial lesion syndrome diagnosed and treated in the First Affiliated Hospital of Nanchang University from January 2017 to May 2019 were included. The clinical manifestations were headache, dizziness, fever, convulsions, disturbance of consciousness, all 23 patients in this group had decreased serum albumin levels. The common feature of head MRI was a reversible isolated lesion of the corpus callosum, which was round ⁃ shaped with clear borders, with high signal on T2WI, low signal on T1WI, high signal on DWI, and low signal on ADC, and the lesions gradually or completely disappeared on the 14th day of onset. Conclusions The etiology and clinical manifestations of reversible splenial lesion syndrome are complicated. MRI usually presents a reversible round ⁃ shaped lesion in the corpus callosum. Imaging lesions usually disappear earlier than clinical symptoms. The decrease of serum albumin level may be a risk factor for cytotoxic edema.

Keywords

• corpus callosum
• serum albumin
• edema
• magnetic resonance imaging