OncoTargets and Therapy (Jun 2020)
Primary Urothelium Carcinoma of the Distal Urethra in a Male: Case Report and Literature Review
Abstract
Ning Wang,1,2 Jingxian Min,3 Qiang Wei,4 Wanlong Tan,4 Qiang Dang4 1Department of Radiotherapy, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of China; 2Department of Oncology, Kanghua Hospital, Dongguan City, Guangdong Province 523000, People’s Republic of China; 3Department of Health Management, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of China; 4Department of Urology, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of China Correspondence: Qiang Dang; Wanlong TanDepartment of Urology, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of ChinaTel +86-20-61641766Email [email protected] TanDepartment of Urology, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of ChinaEmail [email protected]: Male primary urethral urothelium carcinoma is a rare clinical case. Here, we detail a case of a 58-year-old man with primary urothelium carcinoma of the distal urethra treated in our hospital. The patient with a neoplasm inside the external urethral orifice for 2 years, which was previously diagnosed as condyloma acuminata, had received photodynamic therapy for 3 times, with initial symptoms of urinary stream bifurcation and dysuria. The exfoliative urine cytology showed negative. Cystoscopy showed a tumor growing around the distal urethra. Biopsy and immunohistochemistry revealed high-grade papillary urothelium carcinoma. The patient received partial urethrectomy, followed by urinary bladder irrigation chemotherapy with epirubicin postoperatively. The corpus spongiosum was invaded while the corpus cavernosa were not. Postoperative pathological examination showed high-grade invasive urothelium carcinoma. There is no evidence of tumor recurrence, metastasis or surgical complications during a 61-month follow-up period. Male primary urethral urothelium carcinoma is a rare clinical case with particular clinical and pathological characteristics. There are still no established treatment guidelines and should be studied further.Keywords: primary urethral carcinoma, urothelium carcinoma, distal urethra, partial urethrectomy, photodynamic therapy
