BMJ Open (May 2024)

Cohort profile: EFTER-COVID – a Danish nationwide cohort for assessing the long-term health effects of the COVID-19 pandemic

  • Anders Hviid,
  • Steen Ethelberg,
  • Peter Bager,
  • Nete Munk Nielsen,
  • Anders Koch,
  • Anna Irene Vedel Sørensen,
  • Lampros Spiliopoulos

DOI
https://doi.org/10.1136/bmjopen-2024-087799
Journal volume & issue
Vol. 14, no. 5

Abstract

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Purpose To follow SARS-CoV-2-infected persons up to 18 months after a positive test in order to assess the burden and nature of post acute symptoms and health problems.Participants Persons in Denmark above 15 years of age, who were tested positive for SARS-CoV-2 during 1 September 2020 to 21 February 2023 using a RT-PCR test. As a reference group, three test-negative individuals were selected for every two test-positive individuals by matching on test date.Findings to date In total, 2 427 913 invitations to baseline questionnaires have been sent out and 839 528 baseline questionnaires (34.5%) have been completed. Females, the age group 50–69 years, Danish-born and persons, who had received at least one SARS-CoV-2 vaccination booster dose were more likely to participate. Follow-up questionnaires were sent at 2, 4, 6, 9, 12 and 18 months after the test, with response rates at 42%–54%.Future plans New participants have been recruited on a daily basis from 1 August 2021 to 23 March 2023. Data collection will continue until the last follow-up questionnaires (at 18 months after test) have been distributed in August 2024.