The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) due to abnormal aggregation of tau protein. Researches show that cholinergic system is related to AD, and butyrylcholinesterase (BChE) plays an important role in AD. This article reviews the important role of BChE in the pathogenesis of AD. DOI: 10.3969/j.issn.1672-6731.2017.12.013

Keywords

• Alzheimer disease
• Butyrylcholinesterase
• Review