Pediatrics and Neonatology (Jun 2016)

Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants

  • Bo Bae Kim,
  • Sung-Hoon Chung,
  • Hoi-Soo Yoon,
  • Won-Ho Hahn,
  • Chong-Woo Bae,
  • Yong-Sung Choi

DOI
https://doi.org/10.1016/j.pedneo.2015.08.006
Journal volume & issue
Vol. 57, no. 3
pp. 195 – 200

Abstract

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Transient tachypnea of the newborn (TTN) is a benign disorder with a variable clinical course that often leads to hospitalization. The aim of this study was to assess and validate the relationship between the serum cystatin C level and symptom duration in infants with TTN. Methods: Forty newborns presenting with TTN and who had undergone serum cystatin C (Cys C) tests on the first day of admission to the Kyung Hee University Hospital (Seoul, Korea) from 2009 to 2013 were included. The serum Cys C level, creatinine (Cr) level, estimated glomerular filtration rate (eGFR), and tachypnea duration were correlated retrospectively. Results: The median gestation period was 37.8 ± 3.8 weeks and the mean birth weight was 3.2 ± 0.4 kg. Tachypnea duration was 3.3 ± 2.0 days. Serum Cys C and Cr levels were 1.7 ± 0.2 mg/L and 0.8 ± 1.2 mg/dL, respectively. Tachypnea duration was significantly positively correlated with the serum levels of Cys C and significantly negatively correlated with Cys C-based eGFR (p = 0.016), but was not significantly correlated with the serum Cr level or Cr-based eGFR. When tachypnea duration was compared between infants with Cys C level <1.6 mg/L (n = 15; Group A) and infants with Cys C level ≥ 1.6 mg/L (n = 25; Group B), the symptom duration was significantly shorter in Group A infants (p = 0.011). Conclusion: Tachypnea duration was shorter with higher Cys C-based eGFR in infants with TTN.

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