JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation

Abstract

Here the authors demonstrate that TGFβ drives multi-enhancer contacts and ultimately gene activation during neuronal commitment, and that this requires the intrinsically disordered region (IDR) of the histone demethylase JMJD3 likely through its role in promoting phase-separated biomolecular condensates.