Nature Communications (Jul 2017)

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

  • David Richter,
  • Ignacio Moraga,
  • Hauke Winkelmann,
  • Oliver Birkholz,
  • Stephan Wilmes,
  • Markos Schulte,
  • Michael Kraich,
  • Hella Kenneweg,
  • Oliver Beutel,
  • Philipp Selenschik,
  • Dirk Paterok,
  • Martynas Gavutis,
  • Thomas Schmidt,
  • K. Christopher Garcia,
  • Thomas D. Müller,
  • Jacob Piehler

DOI
https://doi.org/10.1038/ncomms15976
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signalling complexes by actin-dependent membrane microdomains.