A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

Jiezhou Pan; Guidong Gong; Qin Wang; Jiaojiao Shang; Yunxiang He; Chelsea Catania; Dan Birnbaum; Yifei Li; Zhijun Jia; Yaoyao Zhang; Neel S. Joshi; Junling Guo

doi:10.1038/s41467-022-29672-z

Nature Communications (Apr 2022)

A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

Jiezhou Pan,
Guidong Gong,
Qin Wang,
Jiaojiao Shang,
Yunxiang He,
Chelsea Catania,
Dan Birnbaum,
Yifei Li,
Zhijun Jia,
Yaoyao Zhang,
Neel S. Joshi,
Junling Guo

Affiliations

Jiezhou Pan: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Guidong Gong: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Qin Wang: School of Pharmacy, Southwest Minzu University
Jiaojiao Shang: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Yunxiang He: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Chelsea Catania: Department of Mechanical Engineering, Massachusetts Institute of Technology
Dan Birnbaum: Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University
Yifei Li: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Zhijun Jia: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Yaoyao Zhang: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Neel S. Joshi: Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University
Junling Guo: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University

DOI: https://doi.org/10.1038/s41467-022-29672-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Here, the authors develop a polyphenol-based single-cell coating that forms a nanoarmor on the surface of probiotics, showing that protects from a wide range of antibiotics and enhances probiotic action against antibiotic-mediated diarrhea.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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