Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers

Abstract

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function and not affecting the electrophysiological parameters of the heart. This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a wide range of HCN channel blockers.

Keywords

• antiarrhythmics
• cardioprotectors
• hcn-channels blockers
• biaromatic compounds