Фармакокинетика и Фармакодинамика (Jul 2022)

Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers

  • G. V. Mokrov

DOI
https://doi.org/10.37489/2587-7836-2022-2-03-10
Journal volume & issue
Vol. 0, no. 2
pp. 3 – 10

Abstract

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Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function and not affecting the electrophysiological parameters of the heart. This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a wide range of HCN channel blockers.

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