Frontiers in Physiology (Oct 2021)
Differential Regulation of the Asthmatic Phenotype by the Aryl Hydrocarbon Receptor
- Hussein Traboulsi,
- Hussein Traboulsi,
- Hussein Traboulsi,
- Angela Rico de Souza,
- Angela Rico de Souza,
- Benoit Allard,
- Zahraa Haidar,
- Zahraa Haidar,
- Zahraa Haidar,
- Mark Sorin,
- Mark Sorin,
- Mark Sorin,
- Vanessa Moarbes,
- Vanessa Moarbes,
- Vanessa Moarbes,
- Elizabeth D. Fixman,
- Elizabeth D. Fixman,
- Elizabeth D. Fixman,
- James G. Martin,
- James G. Martin,
- James G. Martin,
- David H. Eidelman,
- David H. Eidelman,
- David H. Eidelman,
- Carolyn J. Baglole,
- Carolyn J. Baglole,
- Carolyn J. Baglole,
- Carolyn J. Baglole,
- Carolyn J. Baglole
Affiliations
- Hussein Traboulsi
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Hussein Traboulsi
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Hussein Traboulsi
- Department of Medicine, McGill University, Montreal, QC, Canada
- Angela Rico de Souza
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Angela Rico de Souza
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Benoit Allard
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Zahraa Haidar
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Zahraa Haidar
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Zahraa Haidar
- Department of Medicine, McGill University, Montreal, QC, Canada
- Mark Sorin
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Mark Sorin
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Mark Sorin
- Department of Medicine, McGill University, Montreal, QC, Canada
- Vanessa Moarbes
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Vanessa Moarbes
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Vanessa Moarbes
- Department of Medicine, McGill University, Montreal, QC, Canada
- Elizabeth D. Fixman
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Elizabeth D. Fixman
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Elizabeth D. Fixman
- Department of Medicine, McGill University, Montreal, QC, Canada
- James G. Martin
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- James G. Martin
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- James G. Martin
- Department of Medicine, McGill University, Montreal, QC, Canada
- David H. Eidelman
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- David H. Eidelman
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- David H. Eidelman
- Department of Medicine, McGill University, Montreal, QC, Canada
- Carolyn J. Baglole
- Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Carolyn J. Baglole
- Translational Research in Respiratory Diseases Program at the Research Institute of the McGill University Health Centre, Montreal, QC, Canada
- Carolyn J. Baglole
- Department of Medicine, McGill University, Montreal, QC, Canada
- Carolyn J. Baglole
- Department of Pathology, McGill University, Montreal, QC, Canada
- Carolyn J. Baglole
- Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
- DOI
- https://doi.org/10.3389/fphys.2021.720196
- Journal volume & issue
-
Vol. 12
Abstract
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates the metabolism of xenobiotics. There is growing evidence that the AhR is implicated in physiological processes such proliferation, differentiation, and immune responses. Recently, a role of the AhR in regulating allergic asthma has been suggested, but whether the AhR also regulates other type of asthma, particularly occupational/irritant-induced asthma, remains unknown. Using AhR-deficient (Ahr−/−) mice, we compared the function of the AhR in the response to ovalbumin (OVA; allergic asthma) vs. chlorine (Cl2; irritant-induced asthma) exposure. Lung inflammation and airway hyperresponsiveness were assessed 24h after exposure to Cl2 or OVA challenge in Ahr−/− and heterozygous (Ahr+/−) mice. After OVA challenge, absence of AhR was associated with significantly enhanced eosinophilia and lymphocyte influx into the airways of Ahr−/− mice. There were also increased levels of interleukin-4 (IL-4) and IL-5 in the airways. However, OVA-induced airway hyperresponsiveness was not affected. In the irritant-induced asthma model caused by exposure to Cl2, the AhR did not regulate the inflammatory response. However, absence of AhR reduced Cl2-induced airway hyperresponsiveness. Collectively, these results support a differential role for the AhR in regulating asthma outcomes in response to diverse etiological agents.
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