Hippo pathway and its research progress in ophthalmology

Abstract

The Hippo pathway, regulated by multiple intracellular and extracellular signals, is an evolutionarily conserved signaling pathway. Through YAP/TAZ,the effector molecule, Hippo pathway participates in a variety of important physiological activities such as regulating the proliferation, differentiation, migration and regeneration of cells. Extensive studies have revealed that the Hippo pathway involves in tissue development, organ regeneration and tumorigenesis. Recent studies have shown that the Hippo pathway is closely related to the development and regeneration of ocular tissues and development of ocular diseases. Elucidating the role of Hippo pathway in ocular tissues will help to reveal the mechanism of occurrence and development of ophthalmic diseases, and it has far-reaching significance for improving the basic research and guiding the clinical work of ophthalmology. In this manuscript, the components and functions of the Hippo pathway and the recent research progress of Hippo pathway in ocular tissues such as cornea, trabecular meshwork, lens, retina and uvea were reviewed.

Keywords

• hippo pathway
• development
• regeneration
• lens
• retina