Rheumatic immune-related adverse events from checkpoint inhibitor therapy: a case series

Abstract

Immune checkpoint inhibitors (ICIs) targeting cytotoxic Tlymphocyte associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and its ligand PD-L1 are established cancer immunotherapies for solid tumor and hematologic malignancies. These therapies are involved in immune-related adverse events (irAE), both general and rheumatic ones. In general, immune- related adverse events (irAE) management includes drugholding, tapering doses of corticosteroids, and specific immunosuppression for clinically severe cases, such as infliximab or mycophenolate.

Keywords

• immune checkpoint inhibitors (icis)
• rheumatic immunerelated adverse events (irae)