Nature Communications (Jan 2023)
SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
- Valentino Bezzerri,
- Valentina Gentili,
- Martina Api,
- Alessia Finotti,
- Chiara Papi,
- Anna Tamanini,
- Christian Boni,
- Elena Baldisseri,
- Debora Olioso,
- Martina Duca,
- Erika Tedesco,
- Sara Leo,
- Monica Borgatti,
- Sonia Volpi,
- Paolo Pinton,
- Giulio Cabrini,
- Roberto Gambari,
- Francesco Blasi,
- Giuseppe Lippi,
- Alessandro Rimessi,
- Roberta Rizzo,
- Marco Cipolli
Affiliations
- Valentino Bezzerri
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- Valentina Gentili
- Department of Chemical and Pharmaceutical Sciences, University of Ferrara
- Martina Api
- Cystic Fibrosis Center of Ancona, Azienda Ospedaliero Universitaria Ospedali Riuniti
- Alessia Finotti
- Department of Life Sciences and Biotechnology, University of Ferrara
- Chiara Papi
- Department of Life Sciences and Biotechnology, University of Ferrara
- Anna Tamanini
- Section of Molecular Pathology, Azienda Ospedaliera Universitaria Integrata
- Christian Boni
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- Elena Baldisseri
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- Debora Olioso
- Section of Clinical Biochemistry, University of Verona
- Martina Duca
- Cystic Fibrosis Center of Ancona, Azienda Ospedaliero Universitaria Ospedali Riuniti
- Erika Tedesco
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- Sara Leo
- Department of Medical Sciences, University of Ferrara
- Monica Borgatti
- Department of Life Sciences and Biotechnology, University of Ferrara
- Sonia Volpi
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- Paolo Pinton
- Center on Innovative Therapies for Cystic Fibrosis, University of Ferrara
- Giulio Cabrini
- Department of Life Sciences and Biotechnology, University of Ferrara
- Roberto Gambari
- Department of Life Sciences and Biotechnology, University of Ferrara
- Francesco Blasi
- Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano
- Giuseppe Lippi
- Section of Clinical Biochemistry, University of Verona
- Alessandro Rimessi
- Center on Innovative Therapies for Cystic Fibrosis, University of Ferrara
- Roberta Rizzo
- Department of Chemical and Pharmaceutical Sciences, University of Ferrara
- Marco Cipolli
- Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata
- DOI
- https://doi.org/10.1038/s41467-023-35862-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Patients with cystic fibrosis are not reporting particularly sever outcomes upon SARS-CoV-2 infection. Here, the authors demonstrate decreased ACE2 levels is cystic fibrosis airway epithelia associated with impaired viral entry and replication.
