Nature Communications (Jan 2018)

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

  • Roselle Gélinas,
  • Florence Mailleux,
  • Justine Dontaine,
  • Laurent Bultot,
  • Bénédicte Demeulder,
  • Audrey Ginion,
  • Evangelos P. Daskalopoulos,
  • Hrag Esfahani,
  • Emilie Dubois-Deruy,
  • Benjamin Lauzier,
  • Chantal Gauthier,
  • Aaron K. Olson,
  • Bertrand Bouchard,
  • Christine Des Rosiers,
  • Benoit Viollet,
  • Kei Sakamoto,
  • Jean-Luc Balligand,
  • Jean-Louis Vanoverschelde,
  • Christophe Beauloye,
  • Sandrine Horman,
  • Luc Bertrand

DOI
https://doi.org/10.1038/s41467-017-02795-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

Read online

AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation.