Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Renxu Chang; Lele Song; Yi Xu; Yanjun Wu; Cheng Dai; Xinyu Wang; Xia Sun; Yingyong Hou; Wei Li; Xianbao Zhan; Lixing Zhan

doi:10.1038/s41467-018-05852-8

Nature Communications (Aug 2018)

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Renxu Chang,
Lele Song,
Yi Xu,
Yanjun Wu,
Cheng Dai,
Xinyu Wang,
Xia Sun,
Yingyong Hou,
Wei Li,
Xianbao Zhan,
Lixing Zhan

Affiliations

Renxu Chang: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Lele Song: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Yi Xu: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Yanjun Wu: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Cheng Dai: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Xinyu Wang: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Xia Sun: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences
Yingyong Hou: Department of Pathology, Zhongshan Hospital, Fudan University
Wei Li: Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Xianbao Zhan: Department of Oncology, Changhai Hospital, Second Military Medical University
Lixing Zhan: Key Laboratory of Nutrition, Metabolism, and Food Safety, Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-05852-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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