Geriatrics (Jun 2024)

Alzheimer’s Disease: Cellular and Pharmacological Aspects

  • Gonzalo Emiliano Aranda-Abreu,
  • Fausto Rojas-Durán,
  • María Elena Hernández-Aguilar,
  • Deissy Herrera-Covarrubias,
  • Lizbeth Donají Chí-Castañeda,
  • María Rebeca Toledo-Cárdenas,
  • Jorge Manuel Suárez-Medellín

DOI
https://doi.org/10.3390/geriatrics9040086
Journal volume & issue
Vol. 9, no. 4
p. 86

Abstract

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Alzheimer’s disease was described more than 100 years ago and despite the fact that several molecules are being tested for its treatment, which are in phase III trials, the disease continues to progress. The main problem is that these molecules function properly in healthy neurons, while neuronal pathology includes plasma membrane disruption, malfunction of various organelles, and hyperphosphorylation of Tau and amyloid plaques. The main objective of this article is the discussion of a neuronal restoration therapy, where molecules designed for the treatment of Alzheimer’s disease would probably be more effective, and the quality of life of people would be better.

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