Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development
Giulia Chinetti,
Joseph Carboni,
Joseph Murdaca,
Claudine Moratal,
Brigitte Sibille,
Juliette Raffort,
Fabien Lareyre,
Elixène Jean Baptiste,
Réda Hassen-Khodja,
Jaap G. Neels
Affiliations
Giulia Chinetti
Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Joseph Carboni
Department of Vascular Surgery, Centre Hospitalier Universitaire (CHU), 06000 Nice, France
Joseph Murdaca
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Claudine Moratal
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Brigitte Sibille
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Juliette Raffort
Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Fabien Lareyre
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Elixène Jean Baptiste
Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Réda Hassen-Khodja
Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Jaap G. Neels
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
Type 2 diabetes patients are less likely to develop an abdominal aortic aneurysm (AAA). Since macrophages play a crucial role in AAA development, we hypothesized that this decrease in AAA risk in diabetic patients might be due to diabetes-induced changes in macrophage biology. To test this hypothesis, we treated primary macrophages obtained from healthy human volunteers with serum from non-diabetic vs. diabetic AAA patients and observed differences in extracellular acidification and the expression of genes involved in glycolysis and lipid oxidation. These results suggest an increase in metabolism in macrophages treated with serum from diabetic AAA patients. Since serum samples used did not differ in glucose content, these changes are not likely to be caused by differences in glycemia. Macrophage functions have been shown to be linked to their metabolism. In line with this, our data suggest that this increase in macrophage metabolism is accompanied by a shift towards an anti-inflammatory state. Together, these results support a model where diabetes-induced changes in metabolism in macrophages might lead to a reduced risk for AAA development.
