Vitamin C epigenetically controls osteogenesis and bone mineralization

• Roman Thaler,
• Farzaneh Khani,
• Janet M. Denbeigh,
• Ines Sturmlechner,
• Xianhu Zhou,
• Oksana Pichurin,
• Amel Dudakovic,
• Jiang Zhong,
• Jeong-Heon Lee,
• Ramesh Natarajan,
• Ivo Kalajzic,
• David R. Deyle,
• Eleftherios P. Paschalis,
• Barbara Misof,
• Tamas Ordog,
• Andre J. van Wijnen

Affiliations

Roman Thaler

Department of Orthopedic Surgery, Department of Biochemistry & Molecular Biology, Center for Regenerative Medicine, Mayo Clinic, Rochester, United States; Corresponding author.

Farzaneh Khani

Department of Orthopedic Surgery, Mayo Clinic, Rochester, United States

Janet M. Denbeigh

Department of Orthopedic Surgery, Mayo Clinic, Rochester, United States

Ines Sturmlechner

Departments of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, United States; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

Xianhu Zhou

Department of Orthopedic Surgery, Mayo Clinic, Rochester, United States

Oksana Pichurin

Department of Orthopedic Surgery, Mayo Clinic, Rochester, United States

Amel Dudakovic

Department of Orthopedic Surgery, Mayo Clinic, Rochester, United States

Jiang Zhong

Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, United States

Jeong-Heon Lee

Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, United States

Ramesh Natarajan

Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States

Ivo Kalajzic

Department of Reconstructive Sciences, UConn Health, Farmington, United States

David R. Deyle

Department of Medical Genetics, Mayo Clinic, Rochester, United States

Eleftherios P. Paschalis

1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of Social Health Insurance Vienna (WGKK) and Austrian Social Insurance for Occupational Risk (AUVA), Vienna, Austria

Barbara Misof

1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of Social Health Insurance Vienna (WGKK) and Austrian Social Insurance for Occupational Risk (AUVA), Vienna, Austria

Tamas Ordog

Epigenomics Program, Center for Individualized Medicine, Department of Physiology and Biomedical Engineering and Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, United States

Andre J. van Wijnen

Department of Orthopedic Surgery, Department of Biochemistry & Molecular Biology, Center for Regenerative Medicine, Mayo Clinic, Rochester, United States