New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)
Jéssica K. S. Maciel,
Otemberg S. Chaves,
Severino G. Brito Filho,
Yanna C. F. Teles,
Marianne G. Fernandes,
Temilce S. Assis,
Pedro Dantas Fernandes,
Alberício Pereira de Andrade,
Leonardo P. Felix,
Tania M. S. Silva,
Nathalia S. M. Ramos,
Girliane R. Silva,
Maria de Fátima Vanderlei de Souza
Affiliations
Jéssica K. S. Maciel
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil
Otemberg S. Chaves
Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil
Severino G. Brito Filho
Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil
Yanna C. F. Teles
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil
Marianne G. Fernandes
Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil
Temilce S. Assis
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil
Pedro Dantas Fernandes
Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil
Alberício Pereira de Andrade
Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil
Leonardo P. Felix
Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil
Tania M. S. Silva
Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil
Nathalia S. M. Ramos
Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil
Girliane R. Silva
Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil
Maria de Fátima Vanderlei de Souza
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil
The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 132-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7′-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.
