Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Gert-Jan Bekker; Mitsugu Araki; Kanji Oshima; Yasushi Okuno; Narutoshi Kamiya

doi:10.1038/s42003-023-04720-6

Communications Biology (Mar 2023)

Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Gert-Jan Bekker,
Mitsugu Araki,
Kanji Oshima,
Yasushi Okuno,
Narutoshi Kamiya

Affiliations

Gert-Jan Bekker: Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita
Mitsugu Araki: Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku
Kanji Oshima: Bio-Pharma Research Laboratories, KANEKA CORPORATION, 1-8 Miyamae-cho, Takasago-cho
Yasushi Okuno: Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku
Narutoshi Kamiya: Graduate School of Information Science, University of Hyogo, 7-1-28 Minatojima Minami-machi, Chuo-ku

DOI: https://doi.org/10.1038/s42003-023-04720-6
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 11

Abstract

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Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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