Nature Communications (Oct 2020)
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
- Ivan T. Lee,
- Tsuguhisa Nakayama,
- Chien-Ting Wu,
- Yury Goltsev,
- Sizun Jiang,
- Phillip A. Gall,
- Chun-Kang Liao,
- Liang-Chun Shih,
- Christian M. Schürch,
- David R. McIlwain,
- Pauline Chu,
- Nicole A. Borchard,
- David Zarabanda,
- Sachi S. Dholakia,
- Angela Yang,
- Dayoung Kim,
- Han Chen,
- Tomoharu Kanie,
- Chia-Der Lin,
- Ming-Hsui Tsai,
- Katie M. Phillips,
- Raymond Kim,
- Jonathan B. Overdevest,
- Matthew A. Tyler,
- Carol H. Yan,
- Chih-Feng Lin,
- Yi-Tsen Lin,
- Da-Tian Bau,
- Gregory J. Tsay,
- Zara M. Patel,
- Yung-An Tsou,
- Alexandar Tzankov,
- Matthias S. Matter,
- Chih-Jaan Tai,
- Te-Huei Yeh,
- Peter H. Hwang,
- Garry P. Nolan,
- Jayakar V. Nayak,
- Peter K. Jackson
Affiliations
- Ivan T. Lee
- Department of Pathology, Stanford University School of Medicine
- Tsuguhisa Nakayama
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Chien-Ting Wu
- Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine
- Yury Goltsev
- Department of Pathology, Stanford University School of Medicine
- Sizun Jiang
- Department of Pathology, Stanford University School of Medicine
- Phillip A. Gall
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Chun-Kang Liao
- Department of Otolaryngology, National Taiwan University Hospital
- Liang-Chun Shih
- Department of Otorhinolaryngology, China Medical University Hospital
- Christian M. Schürch
- Department of Pathology, Stanford University School of Medicine
- David R. McIlwain
- Department of Pathology, Stanford University School of Medicine
- Pauline Chu
- Department of Pathology, Stanford University School of Medicine
- Nicole A. Borchard
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- David Zarabanda
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Sachi S. Dholakia
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Angela Yang
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Dayoung Kim
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Han Chen
- Department of Pathology, Stanford University School of Medicine
- Tomoharu Kanie
- Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine
- Chia-Der Lin
- Department of Otorhinolaryngology, China Medical University Hospital
- Ming-Hsui Tsai
- Department of Otorhinolaryngology, China Medical University Hospital
- Katie M. Phillips
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Raymond Kim
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Jonathan B. Overdevest
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Matthew A. Tyler
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Carol H. Yan
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Chih-Feng Lin
- Department of Otolaryngology, National Taiwan University Hospital
- Yi-Tsen Lin
- Department of Otolaryngology, National Taiwan University Hospital
- Da-Tian Bau
- Graduate Institute of Biomedical Sciences, China Medical University
- Gregory J. Tsay
- School of Medicine, China Medical University
- Zara M. Patel
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Yung-An Tsou
- Department of Otorhinolaryngology, China Medical University Hospital
- Alexandar Tzankov
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Matthias S. Matter
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Chih-Jaan Tai
- Department of Otorhinolaryngology, China Medical University Hospital
- Te-Huei Yeh
- Department of Otolaryngology, National Taiwan University Hospital
- Peter H. Hwang
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Garry P. Nolan
- Department of Pathology, Stanford University School of Medicine
- Jayakar V. Nayak
- Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine
- Peter K. Jackson
- Department of Pathology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19145-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers.
