PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Mengran Qiao; Mian Wu; Ronghua Shi; Wanglai Hu

doi:10.1038/s41598-017-02982-9

Scientific Reports (Jun 2017)

PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Mengran Qiao,
Mian Wu,
Ronghua Shi,
Wanglai Hu

Affiliations

Mengran Qiao: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China
Mian Wu: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China
Ronghua Shi: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China
Wanglai Hu: Department of Immunology, Anhui Medical University

DOI: https://doi.org/10.1038/s41598-017-02982-9
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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