Nature Communications (Jul 2016)

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

  • Dong-Hyun Kim,
  • Sanghoon Kwon,
  • Sangwon Byun,
  • Zhen Xiao,
  • Sean Park,
  • Shwu-Yuan Wu,
  • Cheng-Ming Chiang,
  • Byron Kemper,
  • Jongsook Kim Kemper

DOI
https://doi.org/10.1038/ncomms12179
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small Heterodimer Partner (SHP), an orphan nuclear receptor.