Dental Hypotheses (Apr 2024)

Assessment of Cytological Changes of Oral Mucosa in the Patients with Gastroesophageal Reflux Disease: An Analytical Cross-Sectional Study

  • Nakisa Torabinia,
  • Firoozeh Samim,
  • Samane Khatoonabadi,
  • Alireza Motamedi,
  • Parvaneh Badri,
  • Forooz Keshani

DOI
https://doi.org/10.4103/denthyp.denthyp_9_24
Journal volume & issue
Vol. 15, no. 2
pp. 19 – 21

Abstract

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Introduction: This study aims to investigate cytological changes of oral mucosa in patients with gastroesophageal reflux disease (GERD). Methods: In this cross-sectional study, 25 patients with GERD and 25 healthy persons underwent buccal mucosa brush biopsy for cytological assessment. The observed cellular changes were categorized(14) as Class I: normal; Class II: atypical; Class III: intermediate; Class IV:suggestive of cancer; Class V: positive for cancer. Results: All 50 participants (mean age 39.9± 11.8, 24 male) completed the study and were included in statistical analysis. Ordinal logistic regression (overall model test p<0.001) showed GERD was a significant predicator for cytological changes of the oral mucosa (p<0.001). Age and gender were not significant predicators (p˃0.05). Conclusion: GERD is associated with cellular alterations in the buccal mucosa, which can be detected by cytology. The most common outcomes were nuclear hyperchromatism and grade II cellular changes.

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