Frontiers in Oncology (Aug 2015)

Sjogren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia

  • Fatma eAhmed,
  • Osama eRaslan,
  • Razi eMuzaffar,
  • Nadeem eParkar,
  • Nitin eMarwaha,
  • Medhat eOsman

DOI
https://doi.org/10.3389/fonc.2015.00179
Journal volume & issue
Vol. 5

Abstract

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Sjogren Syndrome (SS) is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Flurodoxyglucose position emission tomography/CT (F-18 FDG PET/CT) for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be Mucosa-associated lymphoid tissue (MALT) lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia (LIP).

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