Nature Communications (Sep 2016)
Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
- Makoto Kuwahara,
- Wataru Ise,
- Mizuki Ochi,
- Junpei Suzuki,
- Kohei Kometani,
- Saho Maruyama,
- Maya Izumoto,
- Akira Matsumoto,
- Nobuaki Takemori,
- Ayako Takemori,
- Kenta Shinoda,
- Toshinori Nakayama,
- Osamu Ohara,
- Masaki Yasukawa,
- Tatsuya Sawasaki,
- Tomohiro Kurosaki,
- Masakatsu Yamashita
Affiliations
- Makoto Kuwahara
- Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
- Wataru Ise
- Department of Lymphocyte Differentiation, WPI Immunology Frontier Research Center
- Mizuki Ochi
- Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
- Junpei Suzuki
- Department of Translational Immunology, Translational Research Center, Ehime University Hospital, Shitsukawa
- Kohei Kometani
- Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences
- Saho Maruyama
- Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
- Maya Izumoto
- Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
- Akira Matsumoto
- Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University, Shitsukawa
- Nobuaki Takemori
- Division of Proteomics, Department of Proteo-Medicine, Proteo-Science Center, Ehime University
- Ayako Takemori
- Division of Proteomics, Department of Proteo-Medicine, Proteo-Science Center, Ehime University
- Kenta Shinoda
- Department of Immunology, Graduate School of Medicine
- Toshinori Nakayama
- Department of Immunology, Graduate School of Medicine
- Osamu Ohara
- Department of Technology Development, Human DNA Analysis Group, Kazusa DNA Research Institute
- Masaki Yasukawa
- Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University, Shitsukawa
- Tatsuya Sawasaki
- Division of Cell-Free Sciences, Department of Proteo-Research, Proteo-Science Center, Ehime University
- Tomohiro Kurosaki
- Department of Lymphocyte Differentiation, WPI Immunology Frontier Research Center
- Masakatsu Yamashita
- Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
- DOI
- https://doi.org/10.1038/ncomms12596
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.
