Egyptian Journal of Medical Human Genetics (Dec 2023)

A novel pathogenic splice-site variant in the PTCH1 gene c.3549+1G>T, associated with Gorlin syndrome: a case report

  • Paula Conde-Rubio,
  • Ana Julia García-Malinis,
  • Elvira Salvador-Rupérez,
  • Silvia Izquierdo Álvarez,
  • Ricardo González-Tarancón

DOI
https://doi.org/10.1186/s43042-023-00463-5
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 8

Abstract

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Abstract Background Gorlin syndrome (GS) is a rare genetic disorder inherited in an autosomal dominant manner caused by genetic variants in PTCH1, SUFU, or PTCH2 genes. It is characterized by multiple basal cell carcinomas, odontogenic keratocysts, skeletal abnormalities, and predisposition to neoplasms. Case presentation A novel splice-site variant in the PTCH1 gene, c.3549+1G>T classified as pathogenic, was identified in a patient with a phenotype compatible with GS (multiple basal cell carcinomas and skeletal malformations). Conclusions This case contributes to expand the spectrum of identified variants in Gorlin syndrome increasing knowledge about molecular bases and the diagnosis approach of this syndrome.

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