Infection and Drug Resistance (Dec 2022)

Trends of Rifampicin Resistance in Patients with Pulmonary Tuberculosis: A Longitudinal Analysis Based on Drug Resistance Screening in Eastern China Between 2015 and 2019

  • Ren Y,
  • Chen B,
  • Zhao J,
  • Tan X,
  • Chen X,
  • Zhou L,
  • Wang F,
  • Peng Y,
  • Jiang J

Journal volume & issue
Vol. Volume 15
pp. 7707 – 7717

Abstract

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Yanli Ren,1 Bin Chen,2 Jiaying Zhao,3 Xiaohua Tan,1 Xinyi Chen,2 Lin Zhou,2 Fei Wang,2 Ying Peng,2 Jianmin Jiang1,2 1School of Public Health, Hangzhou Normal University, Hangzhou, People’s Republic of China; 2Zhejiang Center for Disease Control and Prevention, Hangzhou, People’s Republic of China; 3School of Public Health, Xiamen University, Fujian, People’s Republic of ChinaCorrespondence: Ying Peng; Jianmin Jiang, Email [email protected]; [email protected]: To understand the trend of overall rifampicin resistance rates for tuberculosis in Zhejiang Province between 2015 and 2019.Methods: The basic demographic information of patients with tuberculosis who were screened for drug resistance in Zhejiang Province between January 1, 2015 and December 31, 2019 was collected through the national Tuberculosis Information Management System. The data were processed and analyzed using IBM SPSS 26.0 and GeoDa 1.14 software.Results: The total rifampicin resistance rate was 5.9% in 53,893 validated cases of drug resistance screening conducted in patients with pulmonary tuberculosis in Zhejiang Province during the study period. There was a decreasing trend in the rifampicin resistance rate in both initial and re-treated patients (P< 0.001), but the rifampicin resistance rate was higher in re-treated TB patients than in TB patients receiving their initial treatment (11.4% vs 4.2%). The rate of drug resistance steadily decreased in all prefectures, and there was a significant upward trend in the use of the Xpert MTB/RIF rapid assay. An increasing trend was also identified in the rate of rifampicin and ofloxacin co-resistance (P< 0.001).Conclusion: The overall rate of rifampin resistance in patients with tuberculosis in Zhejiang Province in the past five years has shown a decreasing trend, but the rate of resistance to ofloxacin was high. Resistance testing to fluoroquinolones should be carried out as early as possible in patients whose diagnosis results indicate rifampin resistance, and more effective second-line treatment plans should be developed based on the results of this testing.Keywords: rifampicin, drug-resistant tuberculosis, ofloxacin, trend analysis

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