Grape skin and seed extracts as a potential natural solution for hair loss: A bioactivity evaluation

Abstract

Scalp yeast infections and androgenic effects can lead to hair loss respectively by disrupting hair follicle function and by causing miniaturization. Herbal extracts, including grape skin and seed extracts, show promise for hair growth improvement and hair loss prevention due to their safety and diverse biological activities. The aim of this study was to evaluate the antifungal and 5α-reductase inhibition activities of grape skin and seed extracts. The results revealed that grape skin and grape seed extracts exhibited excellent antifungal activity against T. mentagrophytes, M. gypseum, C. albicans, P. ovale, and M. canis in descending order. Furthermore, ethanolic grape skin and seed extracts demonstrated promising anti-hair loss activity through an increase in the proliferation of human hair follicle dermal papilla cells (HFDPC) and 5α-reductase inhibition analyzed in vitro on HFDPC. Therefore, the results of this study imply that grape skin and seed extracts may be utilized in the development of multifunctional hair products with anti-hair loss and antifungal actions.

Keywords

• grape extract
• antifungal activity
• 5α-reductase
• anti-hair loss