Breast (Aug 2020)
Impact of age at diagnosis of metastatic breast cancer on overall survival in the real-life ESME metastatic breast cancer cohort
- Sophie Frank,
- Matthieu Carton,
- Coraline Dubot,
- Mario Campone,
- Barbara Pistilli,
- Florence Dalenc,
- Audrey Mailliez,
- Christelle Levy,
- Véronique D’Hondt,
- Marc Debled,
- Thomas Vermeulin,
- Bruno Coudert,
- Christophe Perrin,
- Anthony Gonçalves,
- Lionel Uwer,
- Jean-Marc Ferrero,
- Jean-Christophe Eymard,
- Thierry Petit,
- Marie-Ange Mouret-Reynier,
- Anne Patsouris,
- Tahar Guesmia,
- Thomas Bachelot,
- Mathieu Robain,
- Paul Cottu
Affiliations
- Sophie Frank
- Institut Curie, Paris-Saint Cloud, 26, Rue d’Ulm, 75005, Paris, France; Corresponding author.Institut Curie 26 rue d’Ulm, 75005, Paris, France.
- Matthieu Carton
- Institut Curie, Paris-Saint Cloud, 26, Rue d’Ulm, 75005, Paris, France
- Coraline Dubot
- Institut Curie, Paris-Saint Cloud, 26, Rue d’Ulm, 75005, Paris, France
- Mario Campone
- Institut de Cancérologie de l’Ouest, site René Gauducheau, Site Hospitalier Nord, Boulevard Jacques Monod, 44800, Saint-Herblain, France
- Barbara Pistilli
- Gustave Roussy, 39, Rue Camille Desmoulins, 94800, Villejuif, France
- Florence Dalenc
- Institut Claudius Régaud, 1, Av Irène Joliot Curie, 31059, Toulouse, France
- Audrey Mailliez
- Centre Oscar Lambret, 3, Rue Frédéric Combemale, 59000, Lille, France
- Christelle Levy
- Centre François Baclesse, 3, Avenue du Général Harris, 14000, Caen, France
- Véronique D’Hondt
- Institut du Cancer de Montpellier, 208, Av. Apothicaires, 34298, Montpellier, France
- Marc Debled
- Institut Bergonié, 229, Cours de l’Argonne, 33000, Bordeaux, France
- Thomas Vermeulin
- Centre Henri Becquerel, Rue d’Amiens, 76038, Rouen, France
- Bruno Coudert
- Centre Georges-François Leclerc, 1, Rue du Professeur Marion, 21079, Dijon, France
- Christophe Perrin
- Centre Eugène Marquis, Avenue de la Bataille Flandre Dunkerque, 35042, Rennes, France
- Anthony Gonçalves
- Institut Paoli-Calmettes, 232, BD Ste Marguerite, 13009, Marseille, France
- Lionel Uwer
- Institut de Cancérologie de Lorraine, 6, Avenue Bourgogne, 54519, Vandoeuvre les Nancy, France
- Jean-Marc Ferrero
- Centre Antoine Lacassagne, 33, Avenue de Valombrose, 06189, Nice, France
- Jean-Christophe Eymard
- Institut Godinot, 1, Rue du Général Koenig, 51726, Reims, France
- Thierry Petit
- Centre Paul Strauss, 3, Rue de la Porte de l’Hôpital, 67065, Strasbourg, France
- Marie-Ange Mouret-Reynier
- Centre Jean Perrin, 58, Rue Montalembert, 63011, Clermont Ferrand, France
- Anne Patsouris
- Institut de Cancérologie de l’Ouest, site Paul Papin, 15, Rue André Boquel, 49055, Angers, France
- Tahar Guesmia
- R&D Unicancer, 67 avenue Fontainebleau 94270 Le Kremlin Bicêtre, France
- Thomas Bachelot
- Centre Léon Bérard, 28, Rue Laennec, 69008, Lyon, France
- Mathieu Robain
- R&D Unicancer, 67 avenue Fontainebleau 94270 Le Kremlin Bicêtre, France
- Paul Cottu
- Institut Curie, Paris-Saint Cloud, 26, Rue d’Ulm, 75005, Paris, France
- Journal volume & issue
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Vol. 52
pp. 50 – 57
Abstract
Background: Young age is a poor prognostic factor in early stage breast cancer (BC) but its value is less established in metastatic BC (MBC). We evaluated the impact of age at MBC diagnosis on overall survival (OS) across three age groups ( 60 years(y)). Methods: ESME MBC database is a national cohort, collecting retrospective data from 18 participating French cancer centers between January 01, 2008 and December 31, 2014. Results: Among 14 403 women included, 1077 (7.5%), 6436 (44.7%) and 6890 (47.8%) pts were 60 y respectively. Pts 60y) and triple negative subtypes (27.4 vs 14.6% in >60y), and more frequent visceral involvement (36.3 vs 29.8% in >60y). At a median follow-up of 48 months, median OS differed across age groups: 38.8, 38.4 and 35.6 months for pts 60y, respectively (p 60y, respectively (p < 0.0001). Conclusion: Although young age seems associated with more aggressive presentations at diagnosis of MBC, it has no deleterious effect on OS in this large series.
