Nature Communications (Oct 2019)

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

  • Sukyeong Kim,
  • Sangbin Han,
  • Yeongjae Kim,
  • Hyeon-Seop Kim,
  • Young-Ran Gu,
  • Donghyun Kang,
  • Yongsik Cho,
  • Hyeonkyeong Kim,
  • Jeeyeon Lee,
  • Yeyoung Seo,
  • Moon Jong Chang,
  • Chong Bum Chang,
  • Seung-Baik Kang,
  • Jin-Hong Kim

DOI
https://doi.org/10.1038/s41467-019-12910-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

Read online

Osteoarthritis results from the progressive destruction of cartilage matrix. Here, Kim et al. identify tankyrase as a regulator of cartilage matrix anabolism, and find that tankyrase inhibition, by preventing SOX9 PARylation, protects from cartilage destruction in a mouse model of osteoarthritis.