The multifaceted biomimetic titanium implant promotes bone integration with sequential antibacterial and immune modulation properties

Long Chen; Zili Guo; Guowei Duan; Guodong Zhao; Xinyao Liu; Zian Wang; Yuan Liu; Lingling Bai; Hong Xu; Yan Peng; Lei Qiang; Dongbiao Chang; Jun Sheng; Tong Sun; Jie Weng

Bioactive Materials (Sep 2025)

The multifaceted biomimetic titanium implant promotes bone integration with sequential antibacterial and immune modulation properties

Long Chen,
Zili Guo,
Guowei Duan,
Guodong Zhao,
Xinyao Liu,
Zian Wang,
Yuan Liu,
Lingling Bai,
Hong Xu,
Yan Peng,
Lei Qiang,
Dongbiao Chang,
Jun Sheng,
Tong Sun,
Jie Weng

Affiliations

Long Chen: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Zigong Fourth People's Hospital, Zigong, Sichuan, 643000, PR China
Zili Guo: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Guowei Duan: Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; School of Life and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Guodong Zhao: College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, PR China
Xinyao Liu: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Zian Wang: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Yuan Liu: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China
Lingling Bai: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Department of Blood Transfusion, Department of Respiratory Medicine, Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, PR China
Hong Xu: Department of Orthopedic Surgery and Orthopedic Research Institution, West China Hospital, Sichuan University, Chengdu, 610041, PR China
Yan Peng: College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, PR China
Lei Qiang: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Dongbiao Chang: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China
Jun Sheng: Department of Orthopedic, The General Hospital of Western Theater Command of PLA, Chengdu, Sichuan, 610083, PR China; Corresponding author.
Tong Sun: College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, PR China; Corresponding author.
Jie Weng: Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China; Corresponding author.

Journal volume & issue: Vol. 51
pp. 494 – 511

Abstract

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Titanium (Ti) and its alloy implants often face issues such as insufficient tissue adhesion and vulnerability of the bio inert surface. Given that the long-term stability of implants depends on their perfect integration with the surrounding tissues to withstand various environmental stresses, current research mainly focuses on mimicking the structure of the extracellular matrix. The aim is to promote bone tissue formation through regulation of the immune response by metal ions, thereby enhancing the effectiveness of tissue integration. The self-assembled zinc (Zn)-doped hydroxyapatite nanoparticles (nHA) with polydopamine (PDA) and copper ions (Cu2+) was deposited onto the alkali treated Ti surface to fabricate the P-Zn-Cu/Ti coating. The so-constructed multifunctional coating with bionic micro/nano-structures on the Ti surface can achieve the sequential release of Cu2+ and zinc ions (Zn2+) through the rapid release of Cu2+ in the early stage and the slow release of Zn2+, and followed the functional characteristics of sequentially regulating antibacterial, immune, and osteogenic responses. This study presents a promising strategy to address the challenges associated with the failure of Ti implants, thus promoting the development of implant technology and improving clinical efficacy.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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