Molecules (Oct 2023)

Isolation and Identification of Chemical Compounds from <i>Agaricus blazei</i> Murrill and Their In Vitro Antifungal Activities

  • Ruirui Yu,
  • Xiaojian Li,
  • Peng Yi,
  • Ping Wen,
  • Shuhong Wang,
  • Chenghui Liao,
  • Xun Song,
  • Haiqiang Wu,
  • Zhendan He,
  • Chenyang Li

DOI
https://doi.org/10.3390/molecules28217321
Journal volume & issue
Vol. 28, no. 21
p. 7321

Abstract

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This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications.

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