Thiazole formation through a modified Gewald reaction

Abstract

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.

Keywords

• design of experiment (DOE)
• 1,4-dithiane-2,5-diol
• Gewald reaction
• thiazole
• thiophene