Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Michael S. Balzer; Tomohito Doke; Ya-Wen Yang; Daniel L. Aldridge; Hailong Hu; Hung Mai; Dhanunjay Mukhi; Ziyuan Ma; Rojesh Shrestha; Matthew B. Palmer; Christopher A. Hunter; Katalin Susztak

doi:10.1038/s41467-022-31772-9

Nature Communications (Jul 2022)

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Michael S. Balzer,
Tomohito Doke,
Ya-Wen Yang,
Daniel L. Aldridge,
Hailong Hu,
Hung Mai,
Dhanunjay Mukhi,
Ziyuan Ma,
Rojesh Shrestha,
Matthew B. Palmer,
Christopher A. Hunter,
Katalin Susztak

Affiliations

Michael S. Balzer: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Tomohito Doke: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Ya-Wen Yang: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Daniel L. Aldridge: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Hailong Hu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Hung Mai: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Dhanunjay Mukhi: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Ziyuan Ma: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Rojesh Shrestha: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
Matthew B. Palmer: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
Christopher A. Hunter: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Katalin Susztak: Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-022-31772-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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After acute injury, kidneys either successfully repair/regenerate or become fibrotic. Here the authors use scRNA-seq to study adaptive/maladaptive kidney regeneration and identify proinflammatory/fibrotic proximal tubule cells with pharmacologically targetable pyroptosis/ferroptosis signatures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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