Real-world impact of transitioning from one lipoprotein(a) assay to another in a clinical setting

Janeni Jeevanathan; Sigrid M. Blom; Thomas Olsen; Kirsten B. Holven; Erik K. Arnesen; Torleif Trydal; Børge G. Nordestgaard; Michael Sovershaev; Ying Chen; Kjetil Retterstøl; Jacob J. Christensen

American Journal of Preventive Cardiology (Sep 2024)

Real-world impact of transitioning from one lipoprotein(a) assay to another in a clinical setting

Janeni Jeevanathan,
Sigrid M. Blom,
Thomas Olsen,
Kirsten B. Holven,
Erik K. Arnesen,
Torleif Trydal,
Børge G. Nordestgaard,
Michael Sovershaev,
Ying Chen,
Kjetil Retterstøl,
Jacob J. Christensen

Affiliations

Janeni Jeevanathan: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway
Sigrid M. Blom: Novartis Norway AS, Nydalen alle 37, 0484, Oslo, Norway
Thomas Olsen: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway
Kirsten B. Holven: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Aker, P.O. Box 4959 Nydalen, 0424, Oslo, Norway
Erik K. Arnesen: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway
Torleif Trydal: Department of Clinical Research, Sørlandet Hospital, SSHF, P.O. Box 416 Lundsiden, 4604, Kristiansand, Norway
Børge G. Nordestgaard: The Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 2730, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
Michael Sovershaev: Fürst Medical Laboratory, P. O. Box 158 Alnabru, 0614, Oslo, Norway
Ying Chen: Fürst Medical Laboratory, P. O. Box 158 Alnabru, 0614, Oslo, Norway; Oslo Metropolitan University, P. O. Box 4, Norway
Kjetil Retterstøl: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway; The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Aker, P. O. Box 4959 Nydalen, 0424, Oslo, Norway
Jacob J. Christensen: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway; Corresponding author.

Journal volume & issue: Vol. 19
p. 100726

Abstract

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Background and aims: Different lipoprotein(a) [Lp(a)] assays may affect risk stratification of individuals and thus clinical decision-making. We aimed to investigate how transitioning between Lp(a) assays at a large central laboratory affected the proportion of individuals with Lp(a) result above clinical thresholds. Methods: We studied nationwide clinical laboratory data including 185,493 unique individuals (47.7 % women) aged 18-50 years with 272,463 Lp(a) measurements using Roche (2000-2009) and Siemens Lp(a) assay (2009-2019). Results: While the majority of individuals (66-75 %) had low levels of Lp(a) (50 mg/dL, 40 % more individuals with Lp(a) >100 mg/dL and 80 % more individuals with Lp(a) > 180 mg/dL than the currently used Siemens assay, likely due to calibration differences. Conclusion: Transitioning from one Lp(a) immunoassay to another had significant impact on Lp(a) results, particularly in individuals approaching clinically relevant Lp(a) thresholds.

Published in American Journal of Preventive Cardiology

ISSN: 2666-6677 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/american-journal-of-preventive-cardiology/

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