Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review
Alexandra Corina Faur,
Alina Maria Șișu,
Laura Andreea Ghenciu,
Roxana Iacob,
Emil Robert Stoicescu,
Ovidiu Alin Hațegan,
Mărioara Cornianu
Affiliations
Alexandra Corina Faur
Department of Anatomy and Embryology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timișoara, Romania
Alina Maria Șișu
Department of Anatomy and Embryology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timișoara, Romania
Laura Andreea Ghenciu
Department of Functional Sciences, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timișoara, Romania
Roxana Iacob
Department of Anatomy and Embryology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timișoara, Romania
Emil Robert Stoicescu
Department of Radiology and Medical Imaging, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
Ovidiu Alin Hațegan
Discipline of Anatomy and Embryology, Medicine Faculty, “Vasile Goldis” Western University of Arad, Revolution Boulevard 94, 310025 Arad, Romania
Mărioara Cornianu
Department of Microscopic-Morphology-Morphopathology, ANATPATMOL Research Center, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timișoara, Romania
Salivary gland tumors are a rare and heterogeneous group of neoplasms of the head and neck region. The mixed category of these tumors include the following entities: pleomorphic adenoma (PA), carcinoma ex pleomorphic adenoma (CEPA), salivary carcinosarcoma (CS), and metastasizing PA (MPA). The most common benign tumor of the salivary glands is PA. Metastasis and malignant degeneration have been reported in cases of PA of a salivary gland origin. Judging by their behavior, MPA, CEPA, and CS can be considered aggressive tumors. Invasive CEPA has been identified in the parotid gland more frequently. MPA and CS cases reported in the current literature are rare. In this paper, we present, narratively, the clinico-morphological features of this group of mixed tumors.
