Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mohamed Ahmed; Jared Mackenzie; Liku Tezera; Robert Krause; Barry Truebody; Diana Garay-Baquero; Andres Vallejo; Katya Govender; John Adamson; Hayden Fisher; Jonathan W. Essex; Salah Mansour; Paul Elkington; Adrie J. C. Steyn; Alasdair Leslie

doi:10.1038/s42003-022-04265-0

Communications Biology (Dec 2022)

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mohamed Ahmed,
Jared Mackenzie,
Liku Tezera,
Robert Krause,
Barry Truebody,
Diana Garay-Baquero,
Andres Vallejo,
Katya Govender,
John Adamson,
Hayden Fisher,
Jonathan W. Essex,
Salah Mansour,
Paul Elkington,
Adrie J. C. Steyn,
Alasdair Leslie

Affiliations

Mohamed Ahmed: Africa Health Research Institute
Jared Mackenzie: Africa Health Research Institute
Liku Tezera: NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
Robert Krause: Africa Health Research Institute
Barry Truebody: Africa Health Research Institute
Diana Garay-Baquero: NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
Andres Vallejo: NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
Katya Govender: Africa Health Research Institute
John Adamson: Africa Health Research Institute
Hayden Fisher: Biological Sciences, University of Southampton
Jonathan W. Essex: School of Chemistry, University of Southampton
Salah Mansour: NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
Paul Elkington: NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
Adrie J. C. Steyn: Africa Health Research Institute
Alasdair Leslie: Africa Health Research Institute

DOI: https://doi.org/10.1038/s42003-022-04265-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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Mycobacterium tuberculosis senses IFN-γ via the membrane protein MmpL10, which results in stimulation of bacterial respiration and virulence gene expression, worsens infection and paradoxically prevents the formation of isoniazid tolerant persisters.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal