The study of Antiviral Effects of Glycyrrihza Glabra Extract on HSV

Abstract

Backround: Recently, resistance to anti viral drugs has been reported. Hence, study of other components for obtaining new treatment approaches is necessary. Objective: The main objective of this study is to determine the inhibitory effect of Glycyrrihza Glabra on HSV replication. Methods: The first step was to evaluate the concentration of Glycyrrihza Glabra which was non toxic for Vero cells. Then, antiviral effects of Glycyrrihza Glabra in non toxic concentration zone were determined through TCID50 Method. IF method was also used in order to determine the reduction of viral proteins. Results: The results indicated that inhibitory effects of Glycyrrihza Glabra on replication of HSV are related to primary time of replication cycle. Conclusion: Glycyrrihza Glabra extract can be a suitable choice for treatment due to HSV infection.

Keywords

• herpes simplex
• glycyrrihza glabra
• cytotoxicity