Correlation and consistency analysis between various indirect portal pressure gradients and actual portal pressure gradient

Abstract

Abstract Objective To evaluate the correlation and consistency between hepatic venous pressure gradient(F-HVPG) calculated as the wedged hepatic venous pressure (WHVP) minus free hepatic venous pressure (FHVP), I-HVPG calculated as WHVP minus inferior vena cava pressure (IVCP) in the hepatic segment, and portal pressure gradient (PPG). Methods Data were collected from 112 patients with portal hypertension undergoing transjugular intrahepatic portosystemic shunt (TIPS) along with HVPG measurement. FHVP, IVCP, WHVP, and portal venous pressure (PVP) were collected intraoperatively. Pearson’s correlation and Bland–Altman method were used to assess correlation and consistency. Results A total of 112 patients were retrospectively collected. The correlation coefficient (r) values (p 2 mmHg, the (r) values (p 2 mmHg. These results suggest that I-HVPG may serve as a more reliable alternative. Due to the significant underestimation of the PPG, HVPG measurement should not be used to exclude patients from a TIPS intervention.

Keywords

• Portal hypertension
• Inferior vena cava pressure
• Portal pressure gradient
• Hepatic venous pressure gradient
• Transjugular intrahepatic portosystemic shunt (TIPS)