PLoS ONE (Apr 2011)

Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.

  • Aiyun Song,
  • Min Xu,
  • Yufang Bi,
  • Yu Xu,
  • Yun Huang,
  • Mian Li,
  • Tiange Wang,
  • Yaohua Wu,
  • Yu Liu,
  • Xiaoying Li,
  • Yuhong Chen,
  • Weiqing Wang,
  • Guang Ning

DOI
https://doi.org/10.1371/journal.pone.0019228
Journal volume & issue
Vol. 6, no. 4
p. e19228

Abstract

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BackgroundPrevious studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.Methodology and principal findingsA community-based cross-sectional study was performed among 5,227 Chinese adults. The average age of our study was 61.5±9.9 years. Serum fetuin-A concentrations were not significantly different between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, pConclusions and significanceHigher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.