PLoS Biology (Aug 2021)

Challenges in interpreting cytokine data in COVID-19 affect patient care and management.

  • Stephen Y Wang,
  • Takehiro Takahashi,
  • Alexander B Pine,
  • William E Damsky,
  • Michael Simonov,
  • Yanhua Zhang,
  • Elizabeth Kieras,
  • Christina C Price,
  • Brett A King,
  • Mark D Siegel,
  • Gary V Desir,
  • Alfred I Lee,
  • Akiko Iwasaki,
  • Hyung J Chun

DOI
https://doi.org/10.1371/journal.pbio.3001373
Journal volume & issue
Vol. 19, no. 8
p. e3001373

Abstract

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Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different disease contexts. We suggest mitigation strategies to improve the accuracy of cytokine data, as we learn from experience gained during the COVID-19 pandemic.