Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study
Joon Sung Kim,
Byung-Wook Kim,
Sung Min Park,
Ki-Nam Shim,
Seong Woo Jeon,
Sang-Wook Kim,
Yong Chan Lee,
Hee Seok Moon,
Si Hyung Lee,
Woon Tae Jung,
Jin Il Kim,
Kyoung Oh Kim,
Jong-Jae Park,
Woo Chul Chung,
Jeong Hwan Kim,
Gwang Ho Baik,
Jung Hwan Oh,
Sun Moon Kim,
Hyun Soo Kim,
Chang Heon Yang,
Jin Tae Jung,
Chul Hyun Lim,
Hyun Joo Song,
Yong Sik Kim,
Gwang Ha Kim,
Jie-Hyun Kim,
Jae-Il Chung,
Jun Haeng Lee,
Min Ho Choi,
Jong-Kyoung Choi
Affiliations
Joon Sung Kim
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
Byung-Wook Kim
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
Sung Min Park
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
Ki-Nam Shim
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea
Seong Woo Jeon
Deparment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
Sang-Wook Kim
Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea
Yong Chan Lee
Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Hee Seok Moon
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
Si Hyung Lee
Department of Internal Medicine, Yeungnam University School of Medicine, Daegu, Korea
Woon Tae Jung
Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea
Jin Il Kim
Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Kyoung Oh Kim
Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea
Jong-Jae Park
Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea
Woo Chul Chung
Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
Jeong Hwan Kim
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
Gwang Ho Baik
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea
Jung Hwan Oh
Department of Internal Medicine, St. Paul Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Sun Moon Kim
Department of Internal Medicine, Konyang University Hospital, Daejeon, Korea
Hyun Soo Kim
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Chang Heon Yang
Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea
Jin Tae Jung
Division of Gastroenterology, Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea
Chul Hyun Lim
Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Hyun Joo Song
Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea
Yong Sik Kim
Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea
Gwang Ha Kim
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
Jie-Hyun Kim
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Jae-Il Chung
Department of Internal Medicine, Sahmyook Medical Center, Seoul, Korea
Jun Haeng Lee
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Min Ho Choi
Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
Jong-Kyoung Choi
Department of Internal Medicine, National Medical Center, Seoul, Korea
Background/Aims Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods : The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results : In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusion : s The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.
