The features of esophageal daily pH-monitoring depending on the clinical form of gastroesophageal reflux disease in type 2 diabetic patients

Abstract

Background. The purpose of the study was to determine the features of esophageal daily pH-monitoring depending on the clinical form of gastroesophageal reflux disease in type 2 diabetic patients. Material and methods. Eighty-two patients with type 2 diabetes mellitus and gastroesophageal reflux disease were examined. All patients underwent daily pH-monitoring. Results. The time percentage when esophageal pH was < 4 almost equally exceeded such parameter in the control group (31.7 ± 2.3 % in patients with the esophageal form of gastroesophageal reflux disease and 32.7 ± 2.9 % in patients with extra-esophageal form against 4.5 ± 0.3 % in the control group; p < 0.01). Conclusions. In type 2 diabetic patients with esophageal form of gastroesophageal reflux disease daily pH-monito­ring revealed pH < 4 in the esophagus mostly in vertical position, and in patients with extra-esophageal form — in horizontal position. The esophageal pH disturbance in type 2 diabetic patients with esophageal form of gastroesophageal reflux disease is associated with candida esophagitis, whereas in patients with extra-esophageal manifestations — with duodeno-gastro-esophageal reflux (r = 0.84; p < 0.01; r = 0.71; p < 0.05, respectively).

Keywords

• type 2 diabetes mellitus
• gastroesophageal reflux disease
• esophageal daily pH-monitoring