Journal of Neuroinflammation (Jan 2011)

Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

  • Quispe-Cabanillas Juan G,
  • Oliveira Elaine C,
  • Farias Alessandro S,
  • Moraes Adriel S,
  • Pradella Fernando,
  • de Paula Rosemeire FO,
  • Brandão Carlos,
  • von Glehn Felipe,
  • Longhini Ana,
  • Abreu Cassiana,
  • Damasceno Alfredo,
  • Damasceno Benito P,
  • Balashov Konstantin E,
  • Santos Leonilda MB

DOI
https://doi.org/10.1186/1742-2094-8-2
Journal volume & issue
Vol. 8, no. 1
p. 2

Abstract

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Abstract The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p