Atom- and step-economic synthesis of biaryl-substituted furocoumarins, furoquinolones and furopyrimidines by multicomponent reactions and one-pot synthesis

Abstract

Atom-efficient multicomponent reactions (MCR) and step-efficient one-pot synthesis are developed for the synthesis of biaryl-substituted furocoumarins, furoquinolones, and furopyrimidines. Furocoumarin and furoquinolone derivatives are synthesized by a three-component reaction, followed by the Suzuki coupling reaction. Furopyrimidine derivatives are prepared by the Suzuki coupling and then the three-component reaction. The bromobenzaldehydes are the key bifunctional molecules for the multicomponent and Suzuki coupling reactions.

Keywords

• atom economy
• furocoumarin
• furopyrimidine
• furoquinolone
• multicomponent reaction
• one-pot synthesis
• step economy