Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4

Ya-Lan Chang; Shun-Fu Tseng; Yu-Ching Huang; Zih-Jie Shen; Pang-Hung Hsu; Meng-Hsun Hsieh; Chia-Wei Yang; Silvia Tognetti; Berta Canal; Laia Subirana; Chien-Wei Wang; Hsiao-Tan Chen; Chi-Ying Lin; Francesc Posas; Shu-Chun Teng

doi:10.1038/s41467-017-00080-y

Nature Communications (Jul 2017)

Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4

Ya-Lan Chang,
Shun-Fu Tseng,
Yu-Ching Huang,
Zih-Jie Shen,
Pang-Hung Hsu,
Meng-Hsun Hsieh,
Chia-Wei Yang,
Silvia Tognetti,
Berta Canal,
Laia Subirana,
Chien-Wei Wang,
Hsiao-Tan Chen,
Chi-Ying Lin,
Francesc Posas,
Shu-Chun Teng

Affiliations

Ya-Lan Chang: Department of Microbiology, College of Medicine, National Taiwan University
Shun-Fu Tseng: Department of Microbiology, College of Medicine, National Taiwan University
Yu-Ching Huang: Department of Microbiology, College of Medicine, National Taiwan University
Zih-Jie Shen: Department of Microbiology, College of Medicine, National Taiwan University
Pang-Hung Hsu: Department of Bioscience and Biotechnology, National Taiwan Ocean University
Meng-Hsun Hsieh: Department of Microbiology, College of Medicine, National Taiwan University
Chia-Wei Yang: Department of Microbiology, College of Medicine, National Taiwan University
Silvia Tognetti: Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
Berta Canal: Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
Laia Subirana: Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
Chien-Wei Wang: Department of Microbiology, College of Medicine, National Taiwan University
Hsiao-Tan Chen: Department of Microbiology, College of Medicine, National Taiwan University
Chi-Ying Lin: Department of Microbiology, College of Medicine, National Taiwan University
Francesc Posas: Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
Shu-Chun Teng: Department of Microbiology, College of Medicine, National Taiwan University

DOI: https://doi.org/10.1038/s41467-017-00080-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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A G1 cell cycle regulatory kinase Cip1 has been identified in budding yeast but how this is regulated is unclear. Here the authors identify cell cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors as regulating Cip1, causing stress induced CDK inhibition and delay in cell cycle progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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