A Rare Case of Radiation-Induced Liver Disease in Treated Abdominal Lymphoma Showing High [<sup>18</sup>F]FDG Avidity and Low EOB Uptake Proportional to the Irradiation Dose
Aya Usami,
Kota Yokoyama,
Junichi Tsuchiya,
Yoshihiro Umezawa,
Kazuma Toda,
Ukihide Tateishi,
Ryoichi Yoshimura
Affiliations
Aya Usami
Department of Radiation Therapeutics and Oncology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Kota Yokoyama
Department of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Junichi Tsuchiya
Department of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Yoshihiro Umezawa
Department of Hematology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Kazuma Toda
Department of Radiation Therapeutics and Oncology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Ukihide Tateishi
Department of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Ryoichi Yoshimura
Department of Radiation Therapeutics and Oncology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
A 44-year-old woman presented with high [18F]FDG uptake liver lesion after six courses of R-CHOP and radiotherapy for abdominal DLBCL, which was misdiagnosed as a hepatic invasion. EOB–MRI showed slight T2 hyperintensity, low-intensity DWI, and decreased EOB uptake in the hepatocellular phase. Compared with the pretreatment planning CT, the liver lesion coincided with the area of >40.5 Gy, resulting in the diagnosis of RILD. At the follow-up [18F]FDG PET/CT 7 months after irradiation, the abnormal liver uptake disappeared. Comparing [18F]FDG PET/CT, EOB–MRI, and planning CT can lead to the correct diagnosis of RILD and avoid unnecessary biopsies and treatment changes.
