Journal of Pain Research (Dec 2020)
Pain Severity and Interference in Different Parkinson’s Disease Cognitive Phenotypes
Abstract
Yenisel Cruz-Almeida,1 Samuel J Crowley,2 Jared Tanner,2 Catherine C Price2,3 1Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; 2Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 3Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USACorrespondence: Catherine C PriceABPP/Cn Tel +1 352-273-5929Email [email protected]: Chronic pain is prevalent in idiopathic Parkinson’s disease (PD) with many individuals also experiencing cognitive deficits negatively impacting everyday life.Methods: In this study, we examine differences in pain severity and interference between 113 nondemented individuals with idiopathic PD who were statistically classified as having low executive function (n=24), low memory function (n=35), no cognitive deficits (n=54). The individuals with PD were also compared to matched non-PD controls (n=64).Results: PD participants with low executive function reported significantly higher pain interference (p< 0.05), despite reporting similar pain severity levels compared to other phenotypes. These differences remained statistically significant, even after accounting for important confounders such as anxiety and depression (p< 0.05).Discussion: Pain interference in those with lower executive function may represent a target for psychosocial interventions for individuals with pain and PD.Keywords: Parkinson’s disease, pain, cognitive function, profiles, phenotypes
